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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSPB1 All Species: 4.55
Human Site: T174 Identified Species: 12.5
UniProt: P04792 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04792 NP_001531.1 205 22783 T174 A P M P K L A T Q S N E I T I
Chimpanzee Pan troglodytes XP_519162 189 20888 Q159 P M P K L A T Q S N E I T I P
Rhesus Macaque Macaca mulatta P02488 172 19774 S142 A D G M L T F S G P K I Q T G
Dog Lupus familis XP_536576 175 20048 V145 S S D G V L T V N G P R K Q A
Cat Felis silvestris
Mouse Mus musculus P14602 209 22995 T178 A P L P K A V T Q S A E I T I
Rat Rattus norvegicus P42930 206 22874 K175 T V E A P L P K A V T Q S A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q00649 193 21653 V163 S P D G M L T V E A P L P K P
Frog Xenopus laevis NP_001087285 213 23719 I182 A P L P K P A I Q S A E I S I
Zebra Danio Brachydanio rerio NP_001008615 199 22360 V169 S C L S P E G V L T V E A P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.7 38 42.4 N.A. 83.7 83 N.A. N.A. 65.8 67.1 62.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 91.7 51.7 55.6 N.A. 90.4 89.8 N.A. N.A. 78 80.2 75.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 13.3 6.6 N.A. 73.3 6.6 N.A. N.A. 13.3 66.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 6.6 20 13.3 N.A. 80 13.3 N.A. N.A. 33.3 80 33.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 45 0 0 12 0 23 23 0 12 12 23 0 12 12 12 % A
% Cys: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 23 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 12 0 0 12 0 0 12 0 12 45 0 0 12 % E
% Phe: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 12 23 0 0 12 0 12 12 0 0 0 0 12 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 12 0 0 0 23 34 12 34 % I
% Lys: 0 0 0 12 34 0 0 12 0 0 12 0 12 12 0 % K
% Leu: 0 0 34 0 23 45 0 0 12 0 0 12 0 0 12 % L
% Met: 0 12 12 12 12 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 12 12 12 0 0 0 0 % N
% Pro: 12 45 12 34 23 12 12 0 0 12 23 0 12 12 23 % P
% Gln: 0 0 0 0 0 0 0 12 34 0 0 12 12 12 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % R
% Ser: 34 12 0 12 0 0 0 12 12 34 0 0 12 12 0 % S
% Thr: 12 0 0 0 0 12 34 23 0 12 12 0 12 34 0 % T
% Val: 0 12 0 0 12 0 12 34 0 12 12 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _